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Modvigil 200 MG


Modvigil is a drug that stimulates the central nervous system, the active ingredient of which is modafinil, belonging to the pharmacological class of analeptics. The figure “200” means the quantitative content of modafinil in mg. Due to the ability to influence some neurometabolic processes in the brain, modafinil is also considered a group of nootropic substances. It has a psychostimulant effect, is used to treat pronounced forms of hypersomnia, accompanied by nocturnal obstructive sleep apnea and narcolepsy.

SKU: MDVGL Category:

General data
Trade brand Modvigil 200
Active substance Modafinil 200 mg
Manufacturer HAB Pharma
Medical Indications Hypersomnia, Narcolepsy
Other areas of application that are not included in general medical practice Increase in sports achievements and indicators (it is forbidden by the Olympic Anti-Doping Committee). Treatment of chronic fatigue, depression, dementia, multiple sclerosis, schizophrenia, nootropic use, withdrawal of withdrawal symptoms and treatment of drug addiction. Modafinil can also suppress appetite, which can lead to overall weight loss.
Therapeutic doses From 100 to 400 mg
Start of action 30-60 minutes
Action time 24 hours

Composition and release form
Mechanism of action
Indications for use
Other uses
Contraindications and side effects
Invention and legal status
Composition and release form

The active ingredient is diphenylmethylsulfinyl acetamide (modafinil). Modafinil is an equivalent mixture of two enantiomers called R-modafinil and S-modafinil, having the same physical properties. Enantiomers are a pair of stereoisomers, that is, substances that have identical chemical composition, but different orientation of the molecule in space (mirror image of each other). Substances are insoluble in water and poorly soluble in most organic solvents. They are homogeneous white crystals.

The only release format is tablets containing 200 mg of the active substance, placed in a foil package (blister). Used orally. In addition to diphenylmethylsulfinyl acetamide, the composition contains auxiliary substances in the form of lactose, talc and others.

Mechanism of action

Despite the fact that dozens of his scientific studies have been carried out over the 20 years of its existence, there is still no complete picture of the understanding of the effects of modafinil on the human body. Based on current data, the adequate psychostimulating effect of the drug is due to a complex action at the level of receptors and the transmission of an electrical impulse to the central nervous system. The corresponding reactions and some effects are fixed empirically (empirically).

Dopaminergic action component

The drug has an effect on several parts of the brain. Pronounced changes in the chemical composition are recorded in the frontal (prefrontal) lobe of the cerebral cortex, structures of the amygdala and striatum. In these areas, the concentration of monoamines – neurotransmitters, including norepinephrine, dopamine, serotonin, increases. These substances initiate a certain chain of chemical reactions leading to a change in the electrical indices of the membranes of nerve cells, which is necessary for the transmission of nerve impulses. Thus, the psychostimulating effect is achieved by increasing the concentration of the main monoamines in the brain, as a result of which the rate of onset and transmission of the nerve impulse increases. The concentration of monoamines increases due to inhibition of the reuptake of dopamine molecules and the subsequent activation of its synthesis.

Effect on the hypothalamus

The processes of sleep and wakefulness are largely controlled by the hypothalamus, a small part of the diencephalon. Orexin neurons localized in it and in some other departments are actively involved in maintaining wakefulness and regulating eating behavior. Their total number is small, but numerous processes extend from each neuron, reaching almost all parts of the brain. Modafinil activates the orexin type of neurons, which leads to the initiation of the synthesis of orexin (hypocretin) and further enhance wakefulness, increasing concentration of attention.

The drug also increases the synthesis of histamine in the structures of the hypothalamus. Histamine is a mediator involved in a number of immunological mechanisms, activating inflammatory reactions, and also playing a role in the processes of arousal. An increase in histamine concentration triggers the activation of norepinephrine receptors. The active substance modafinil also reduces the production of GABA – the leading neurotransmitter, providing the process of inhibition.


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